Microscopic testicular sperm extraction results in patients with Klinefelter Syndrome
Keywords:
Klinefelter syndrome, Non-obstructive azoospermia, Male infertility, Micro-TESEAbstract
Our aim was to evaluate the results of microscopic testicular sperm extraction (mTESE) in patients with KS and determined factors affecting the success of mTESE. Medical records of 182 patients with NOA who underwent mTESE operation in our institution between 2015-2022 were retrospectively reviewed. Testicular volume (measured using Prader-orchidometry), serum total testosterone, follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol, prolactin levels of the patients and genetic analysis (karyotype analysis and Y chromosome micro-deletion analysis) were evaluated. A total of 30 patients with KS underwent mTESE. While sperm were found in 15 (50%) of the cases, no sperm was found in 15 (50%). Mean age of the cases was 33.4±6.37 years. While the body mass index (BMI) of the cases was 29.9±4.7, it was 31.9±4.5 kg/m2 in the micro-TESE positive group and 27.8±4.1 kg/m2 in the micro-TESE negative group (p=0.01). FSH (p=0.02) and LH (p=0.04) values were significant lower in TESE (+) group. Micro-TESE is an effective sperm retrieval procedure for patients with KS with NOA. In our study FSH and LH levels were found to be lower and BMI was higher in patients with successful spermatozoa in KS patients.
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